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KMID : 0981820080280040319
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Korean Journal of Laboratory Medicine
2008 Volume.28 No. 4 p.319 ~ p.324
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A Case of ABO*Ael02/O04 Genotype with Typical Phenotype O
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Joo Shin-Young
Park Kyoung-Un
Song Jung-Han
Song Sang-Hoon
Han Kyou-Sup
Chang Ho-Eun
Lee Kyung
Kim Mi-Jung
Shim Yeong-Sook
Kwon Hye-Lin
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Abstract
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Ael is a rare blood type which has the least amount of A antigen among A subgroups. It can be detected by special tests performed to resolve the discrepancy between red cell and serum typing in routine serological typing. The presence of A antigen on Ael red cell is demonstrable only by adsorption and elution tests. An Ael individual does not secret A substance in the saliva and may have anti-A antibody in the serum which is usually less reactive with the reagent red cells than anti-B antibody. In Korea, Ael02 has been reported more frequently than other Ael alleles. We report a case of Ael02/O04 who presented as typical phenotype O with strong anti-A and anti-B antibodies and no A antigen detected even by adsorption and elution tests. The case has been proved to be Ael02/O04 by direct sequencing analysis. In individuals with history of discrepancies in the results of ABO phenotyping, ABO genotyping is needed for an accurate evaluation of their blood type.
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KEYWORD
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Ael, Genotype-phenotype discrepancy, A subgroup
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